A total of 49 people have been killed after a bomb tore through a mosque in Pakistan, according to officials.
Fifty others were wounded in the explosion, which struck a Shia mosque in the southern city of Shikarpur, as worshippers were gathering for Friday prayers.
Dr Shaukat Ali Memon - who is in charge of the city's hospital, where large numbers of the dead and wounded were brought - said many of the injuries were severe.
He appealed to residents to donate blood for the wounded.
Pakistani television has been showing footage of both locals and worshippers rushing the dead and injured to hospital.
So far, no group has has said it was responsible for the explosion, but Shia religious sites have been targeted by Sunni Muslim extremists in the past.
Shikarpur is in Sindh province, roughly 300 miles north of the port city of Karachi.
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